19F MRI for quantitative in vivo cell tracking
نویسندگان
چکیده
منابع مشابه
Customizable PLGA-encapsulated perfluorocarbon particles for in vivo 19F MRI
Introduction Magnetic Resonance Imaging (MRI) using H spins from water is a major in vivo imaging modality. With F MRI, cells labeled with fluorinated compounds can be visualized in the body without interference of the large H background from mobile water in tissues. Importantly, it also allows quantification of the number of cells directly from the image data [1, 2]. However, the perfluorocarb...
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Introduction: MRI is a promising tool for monitoring stem cell based therapy. Conventionally, cells are loaded in vitro with iron oxide particles, which appear hypointense on 1H MR images. However, the cell signal is not specific due to ambiguous background and not quantitative. An emerging field to overcome these drawbacks is 19F MRI of cells labeled with perfluorocarbon (PFC) emulsions [1]. F...
متن کاملQuantitative dynamic 19F MRI oximetry in a phantom simulating hypoxia
Introduction Tumor hypoxia is well known to reduce cancer treatment efficacy [1]. Hypoxic tumor cells, which have decreased oxygen levels (pO2), are more resistant to radiotherapy and chemotherapy. Dissolved oxygen influences the F magnetic resonance relaxation times of perfluorocarbons [2]. This property has been used in semiquantitative animal studies to image tumor oxygenation [3]. In this s...
متن کاملEarly assessment of pulmonary inflammation by 19F MRI in vivo.
BACKGROUND Emulsified perfluorocarbons (PFCs) are preferentially phagocytized by monocytes/macrophages and are readily detected by (19)F MRI. This study tests the hypothesis that (19)F MRI can be used to quantitate pulmonary inflammation by tracking of infiltrating PFC-loaded monocytes. METHODS AND RESULTS Pneumonia was induced in mice by intratracheal instillation of lipopolysaccharides (LPS...
متن کاملIn vivo MRI-Based Cell Tracking Using Bio-MPIOs
INTRODUCTION: Previously, we described the fabrication of PLGA encapsulated iron oxide nanoand microparticles (Nkansah, et al, ISMRM 2010). These particles are important advancements for molecular and cellular MRI for a number of reasons. First, they incorporate large amounts of iron, especially relative to dextran coated (U)SPIO. Secondly, PLGA has favorable degradation characteristics, with p...
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ژورنال
عنوان ژورنال: Trends in Biotechnology
سال: 2010
ISSN: 0167-7799
DOI: 10.1016/j.tibtech.2010.04.002